High sensitivity, high resolution, robust iCIEF

Analy system HR
  • Method can be transferred straightforwardly
    from any existing iCIEF or CIEF method.
  • High throughput iCIEF protein separation with consistent high resolution instrument to instrument.
  • Large ID separation column to have high sensitivity, with less clogging.
  • No methylcellulose necessary for cartridge installation and iCIEF with user friendly design fluid path and hydrophilic cartridges

CEInfinite WCID CIEF

Tech 1

Imaged capillary isoelectric focusing (iCIEF) is a high-resolution technique for separating protein mixtures into groups based on their isoelectric point (pI). Compared to conventional CIEF systems, iCIEF provides faster method development, higher detection sensitivity, better reliability, and higher analytical throughput.

CEInfinite WCID CIEF instrument is the only system that empowers dynamic processes investigation with WCID whole column imaging detection . With the application of a high sensitivity CMOS imaging sensor, scan frequency for the whole separation capillary can be as high as 1000 Hz. The increased scan frequency effectively minimizes imaging blur that occurs at a lower scan frequency, which enables dynamic processes, such as Taylor dispersion protein hydrodynamic radius measurement, protein interaction studies, and preparative scanning iCIEF. The capability of CEInfinite to scan at a high frequency opens a new technology of whole column imaging detection, scanning iCIEF.

All CEInfinite iCIEF instruments have a high sensitivity CMOS imaging sensor and powerful deep UV LED light source; this increases the scan rate over 100-fold compared to any other iCIEF systems and allows for the study of dynamic processes.
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Breakthrough high sensitivity imaging CIEF with 200 µm ID imaging cartridge (Compared to that of 100 µm ID one, the sensitivity improvement 100% with the same sample.)

NISTmAb

CEInfinite system has superior resolution and reproducibility to accelerate your biologics development and protein characterizations.

21 CFR Part 11 compliant software

Brand new CEInsight software fully controls the CEInfinite iCIEF system with a user friendly GUI. The CFR control and quantitation software provides reliable operation control, highly efficient data processing, and FDA Title 21 CFR Part 11 compliance.